黄湧课题组成功设计新型的三氮烯导向基团

作者:ito    时间:2012-07-02 00:00:00    点击率:

    碳氢键的活化及官能团化,由于可以提供最直接,最原子经济学的药物分子后期修饰,是目前化学合成领域的研究热点之一。黄湧课题组最近成功设计新型的三氮烯导向基团实现了碳氢活化与官能团化,研究成果以封面形式发表在德国应用化学杂志(影响因子:13.5)。该研究的亮点在于新设计的导向基团可以进行一系列化学官能团的转化,克服了目前碳氢活化中导向基团必须残留在产物结构中的瓶颈。
 


Due to its versatile application to straightfoward and atom economical late stage functionalization of drug candidates, C-H activation/functionalization has emerged as one of the hottest research fields of chemical synthesis. Recently, Yong Huang et. al from SCBB invented a novel triazene directing group for C-H activation and functionalization, published as cover page in the upcoming issue of Angewandte Chemie International Edition (impact factor: 13.5). The highlight of this work lies under the versatility of this newly designed directing group to undergo a series of chemical transformation after C-H activation. It overcomes a vital limitation of this state-of-the-art technology, in which the directing group has to remain part of its products!