洪梅
  • 洪梅

  • 职务:副课题组长,副研究员
  • 电话:+86-755-2153-9221
  • 邮箱:meihong@pkusz.edu.cn
  • 课题组主页:http://web.pkusz.edu.cn/huoyq/
  • 教育背景及工作经历

    教育背景
    2005- 2008        北京大学医学部,生物化学与分子生物学系,尚永丰院士实验室,博士后
    2000- 2005        日本富山医科药科大学,生物化学和病理学联合培养,医学博士,导师:许南浩教授、高野康雄教授,
    1992-1997         北京医科大学,临床医学专业,医学学士
    工作经历
    2015-至今          北京大学深圳研究生院,化学生物学与生物技术学院,副研究员
    2012-2015         兰州大学第二医院泌尿外科研究所,甘肃省泌尿系疾病研究重点实验室,助理研究员
    1997-2000         北京大学人民医院,内科,住院医师

  • 奖项及荣誉

    2000-2005        日本文部省奖学金

  • 研究兴趣

    心脑血管相关疾病及代谢相关疾病
    肿瘤相关基因、信号通路及生物治疗
    转录调控及mRNA降解调控

  • 代表性成果
    1. Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y5, Sodhi A, Smith L, Hong M*, Huo Y*. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017;8(1):584.(*Co-corresponding author)
    2. Xu Y#*, Wang Y#, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li Q, Hong M, Jiang X, Boison D, Weber C, Wu C, Huo Y*. Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Mol Med. 2017;9(9):1263-1278. 
    3. Xu Y, Wang Y, Yan S, Yang Q, Zhou Y, Zeng X, Liu Z, An X, Toque HA, Dong Z, Jiang X, Fulton DJ, Weintraub NL, Li Q, Bagi Z, Hong M, Boison D, Wu C, Huo Y*. Regulation of Endothelial Intracellular Adenosine via Adenosine Kinase Epigenetically Modulates Vascular Inflammation. Nat Commun. (Accepted). 
    4. Tian Y#, Hong M#, Jing S, Liu X, Wang H, Wang X, Kaushik D, Rodriguez R, Wang Z*. Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis. Biomed Res Int. 2017;2017:9591506. doi: 10.1155/2017/9591506.(#Co-first author)
    5. Tian Y#, Hong M#, Guo Q, Chen Z, Jing S, Ma B, Wang H, Rodriguez R, Wang Z*. Clinicopathological and prognostic relevance of EZH2 expression in renal cell carcinoma: A meta-analysis. Int J Clin Exp Med 2016;9(6):9714-9724(#Co-first author)
    6. Tian Y, Gong Y, Pang Y, Wang Z, Hong M*. Clinical and prognostic value of preoperative hydronephrosis in upper tract urothelial carcinoma: a systematic review and meta-analysis. PeerJ. 2016;4:e2144.
    7. Tian Y#, Ma Z#, Chen Z#, Li M, Wu Z, Hong M, Wang H, Svatek R, Rodriguez R, Wang Z*. Clinicopathological and Prognostic Value of Ki-67 Expression in Bladder Cancer: A Systematic Review and Meta-Analysis. PLoS One. 2016;11(7):e0158891.
    8. Yi X, Hong M, Gui B, Chen Z, Li L, Xie G, Liang J, Wang X, Shang Y*. The RNA processing and modification protein, carbon catabolite repression 4, arrests the cell cycle through a p21-dependent and p53-independent pathway. J Biol Chem. 2012; Apr 30. 287(25):21045-57.
    9. Shi B, Liang J, Yang X, Wang Y, Zhao Y, Wu H, Sun L, Zhang Y, Chen Y, Li R, Zhang Y, Hong M, Shang Y*. Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells. Mol Cell Biol. 2007; 27(14):5105-19.
    10. Abdel-Aziz HO, Murai Y, Hong M, Kutsuna T, Takahashi H, Nomoto K, Murata S, Tsuneyama K, Takano Y*. Detection of the JC virus genome in lung cancers: possible role of the T-antigen in lung oncogenesis. Appl Immunohistochem Mol Morphol. 2007;15(4):394-400.
    11. Murai Y, Zheng HC, Aziz HO, Hong M, Kutsuna T, Nakanishi Y, Tsuneyama K, Takano Y*. High JC virus load in gastric cancer and adjacent non-cancerous mucosa. Cancer Sci. 2007; 98(1):25-31.
    12. Zheng H, Murai Y, Hong M, Nakanishi Y, Nomoto K, Masuda S, Tsuneyama K, Takano Y*. JC virus detection in the human tissue specimens. J Clin Pathol. 2007; 60(7):787-93.
    13. Hong M, Murai Y, Kutsuna T, Takahashi H, Nomoto K, Cheng CM, Ishizawa S, Zhao QL, Ogawa R, Harmon BV, Tsuneyama K, Takano Y*. Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells. J Cancer Res Clin Oncol. 2006; 132(1):1-8.
    14. Nakajima A, Kataoka K, Hong M, Sakaguchi M, Huh NH*. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003; 201(2):195-201.