Zhen Yang
  • Zhen Yang

  • Principal Investigator, Changjiang Professor, Dean
  • Tel:+86-755-2603-2971
  • Email:zyang@pku.edu.cn
  • Web:http://web.pkusz.edu.cn/yang
  • Education & Experience

    1989-1992        Ph.D., Chemistry, The Chinese University of Hong Kong, with Professor Henry N. C. Wong

    1983-1986        M.S., Pharmaceutical Chemistry, Shenyang College of Pharmacy, with Professor Qihuai Chen
    1878-1982        B.A., Pharmaceutical Chemistry, Shenyang College of Pharmacy 

    2002-                Changjiang Professor of Chemistry, Dept. of Chemistry, Peking University
    2005-2008        Director of Chemistry, XTL biopharmaceutical Inc. NY
    2001-2005        Co-founders and Director of Chemistry, VivoQuest Inc. NY
    1998-2001         Institute Fellow, Dept. of Cell biology, Harvard Medical School
    1995-1998         Assistant professor, Dept. of Chemistry, The Scripps Research Institute
    1992-1995         Postdoctoral Fellow, Dept. of Chemistry, The Scripps Research Institute, with Professor K. C. Nicolaou 
  • Awards & Honors

    2000        The National Science Fund for Distinguished Young Investigator Award (abroad), NSF of China
    2004        The National Science Fund for Distinguished Young Investigator Award, NSF of China
    2005        Eli Lilly Scientific Excellence Award (China)
    2008        The Asian Core Program Lectureship Award, the Asian Cutting-Edge Organic Chemistry programs
    2009        Baogang Distinguished Teaching Award of Peking University
    2010        Wuxi Pharma Life Science Excellence Award (Golden Medal)
    2011        Editorial advisory board member of ACS“Combinatoial Science”
    2011        Editorial advisory board member of Wiley-VCH “Advanced Synthesis & Catalysis”
    2011        Editorial advisory board member of Springer “Natural Products and Bioprospecting”
    2011        Editorial advisory board member of Royal society “MedChemComm”
    2013       “Zhou Weishan” Synthetic Creative Work Award (Chemical Society of China)
    2013         Nanyue hundred outstanding scholar award (Guangdong Province)
    2013         The first class prize of the Shenzhen Natural Science Award
    2014         The first class prize of the Guangdong Natural Science Award
    2014         The special prize of the Yunnan Natural Science Award

    2016         The second class of National Natural Science Awards

  • Research Fields
    Natural product exists in an infinite range of complexity and diversity, and often presents dazzling biological activities. The total synthesis of complex natural product involves distinct synthetic problems which challenge synthetic chemist ingenuity and skill, and require unique strategies and tactics for their solution. The research program in our group aimed at the development of novel synthetic methodologies and synthetic strategies, and applied them to the syntheses of complex natural products, which is considered highly valuable, attractive, and rewarding, particularly to those who enjoy challenge and wish to acquire the awesome power of creating new chemical entities, and the generated natural product-likes compounds may be valuable for the treatment of diseases and utilized as probes to regulate the importantly biological targets. Currently, we have built up a platform featuring (a) new synthetic methodology program, (b) synthesis program and (c) chemical genetic program.
  • Selected Publications

    1.  Rong, L.; Huang, J.; Shao, W.; Liu, S.; Lan, Y.; Gong, J.; Yang, Z. “Asymmetric Total Synthesis of (-)-Lingzhiol via a Rh-catalysed [3+2] cycloaddition” Nat. Commun. 2014, 55707.
    2.  Zhang, Y.; Luo, T.; Yang, Z. “Strategic Innovation in the Total Synthesis of Complex Natural Products using Gold Catalysis” Nat. Prod. Rep. 2014, 31, 489.
    3.  Yue, G., Zhang, Y.; Fang, L.; Li, C.-C.; Luo, T.; Yang, Z. Collective Synthesis of Cladiellins Based on the Gold-Catalyzed Cascade Reaction of 1,7-Diynes” Angew. Chem. Int. Ed. 201453, 1837.
    4.  Fu, J.; Shang, H.; Wang, Z.; Chang, L.; Shao, W.; Yang, Z.; Tang, Y. “Gold-Catalyzed Rearrangement of Allylic Oxonium Ylides: Efficient Synthesis of Highly Functionalized Dihydrofuran-3-ones” Angew. Chem. Int. Ed. 201352, 4198.
    5.  Wei, H.; Qiao, C.; Liu, G.; Yang, Z.; Li, C.-C. “Asymmetric Total Syntheses of (‒)-Flueggine A and (+)-Virosaine B” Angew. Chem. Int. Ed. 201352, 620.
    6.  Huang, J.; Fang, L.; Long, R.; Shi, L.; Shen, H.; Li, C.-C.; Yang, Z. “Asymmetric Total Synthesis of (+)-Fusarisetin A via the Intramolecular Pauson-Khand Reaction” OrgLett. 201251, 12072.
    7.  Liu, Q.; Yue, G.; Wu, N.; Lin, G.; Li, Y.; Quan, J.; Li, C.; Wang, G.; Yang, Z. “Total Synthesis of (±)-Pentalenolactone A Methyl Este” Angew. Chem. Int. Ed201251, 12072.
    8.  Ren, W.; Bian, Y.; Zhang, Z.; Shang, H.; Zhang, P.; Chen, Y.; Yang, Z.; Luo, T.; Tang, Y. Angew. Chem. Int. Ed201251, 6984.
    9.  Shi, H.; Fang, L.; Tan, C.; Shi, L.; Zhang, W.; Li, C.-C.; Luo, T.; Yang, Z. “Total Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction.” J. Am. Chem. Soc2011132, 14944.
    10.  Xiao, Q.; Ren, W.; Chen, Z.; Sun, T.; Li, Y.; Ye, Q.; Gong, J.; Meng, F.; You, L.; Liu, Y.; Zhao, M.; Xu, L.; Shan, Z.; Shi, Y.; Tang, Y.; Chen, J.; Yang, Z. “Diastereoselective Total Synthesis of (±) Schindilactone A”. Angew. Chem. Int. Ed. 201150, 7373.  
    11.  Gong, J.; Lin, G.; Sun, W.; Li, C.-C.; Yang, Z. “Total Synthesis of (±)-Maoecrystal V” J. Am. Chem. Soc. 2010, 132, 16745.
    12.  Liu, L.; Han, J.; Yue, G.; Li, C.-C.; Yang, Z. “Asymmetric Total Synthesis of Caribenol A.” J. Am. Chem. Soc2010132, 13608.
    13.  Nicolaou, K. C.; Yang, Z.; Shi, G.-Q.; Gunzner, J. L.; Agrios, K. A.; Garttner, P. "Total synthesis of Brevetoxin A" Nature 1998392, 264.
    14.  Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkvic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. "Synthesis of epothilones A and B in solid and solution phase." Nature 1997387, 268.
    15.  Nicolaou, K. C.; Yang, Z.; Liu, J.-J.; Ueno, H.; Nantermet, P. G.; Guy, R. K.; Claiborne, C. F.; Renaud, J.; Couladouros, E. A.; Paulvannan, K.; Sorensen, E. J. “Total synthesis of Taxol”, Nature 1994, 367, 630.