Chao Che
  • Education & Experience
    2010 -                 Associate Professor, Peking University Shenzhen Graduate School
    2009 - 2014        Director of Chemistry, Shenzhen Shengjie Biotech. Co. Ltd.
    2007 - 2009        Associate Professor, Peking University Shenzhen Graduate School
    2005 - 2007        Postdoctoral Fellow, Peking University Shenzhen Graduate School
    2002 - 2005        Ph.D. Institute of Zoology, Chinese Academy of Sciences
    1999 - 2002        M.S. Department of Applied Chemistry, China Agriculture University
    1995 - 1999        B.S. Department of Applied Chemistry, China Agriculture University
  • Awards & Honors
    2007        Excellent Staff, Peking University Shenzhen Graduate School
    2005        The President Award, Chinese Academy of Sciences
    2004        Outstanding Graduate Award, Chinese Academy of Sciences
    1999        Developing Agrochemical Business Award, Beijing Association of Agrochemistry
    1998        Dupont Scholarship Award, China Agricultural University
  • Research Fields
    Development of high-efficient synthetic methodology for diversity-oriented synthesis of small molecules; Target-oriented synthesis of biologically active natural products; Chemical biology.
  • Selected Publications
    1.  Chao Che,* Yang Bo, Jiang Xianlong, Shao Taofeng, Yu Zhixiong, Tao Chuanye, Li Song, and Lin Shuo “Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-Annulation” J. Org. Chem.201479, 436-440.
    2.  Chao Che,* Song Li, Zhixiong Yu, Fangfang Li, Shengchang Xin, Liyan Zhou, Shuo Lin, Zhen Yang* “One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy” ACS Comb. Sci.2013, 15 (4), 202-207.
    3.  Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin,* Zhen Yang* “Synthesis and Characterization of Sant-75 Derivatives as Hedgehog Pathway Inhibitors” Beilstein J. Org. Chem.20128, 841-849.
    4.  Chao Che,* Song Li, Xianlong Jiang, Junmin Quan, Shuo Lin, Zhen Yang* “One-Pot Synthesis of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” Org. Lett.201012, 4682-4685.
    5.  Chao Che, Lianzhu Liu, Jianxian Gong, Yunfang Yang, Guoxin Wang, Junmin Quan, Zhen Yang* “Construction of All Carbon Quarternary Center by AlR2Cl-Mediated Ring-Opening Reaction of Oxacycles” Org. Lett.201012 (3), 488-491.
    6.  Chao Che,* Wenzhao Li, Shengyue Lin, Jiwei Chen,Jie Zheng, Jiunchen Wu, Qunxiong Zheng, Guoqin Zhang, Zhen Yang*, Biwang Jiang* “Magnetic Nanoparticle-Supported Hoveyda-Grubbs Catalysts for Ring-Closing Metathesis Reactions” Chem. Commun.2009, 5990-5992.
    7.  Lianzhu Liu, Yingxiang Gao, Chao Che, Na Wu, Zhigang Wang, Chuangchuang Li, Zhen Yang* “A Model Study for the Concise Construction of the Oxapentacyclic Core of Cortistatins through Intramolecular Diels-Alder and Oxidative Dearomatization-Cyclization Reactions” Chem. Commun.2009(6), 662-664.
    8.  Jing Xiang, Hongbo Yang, Chao Che, Haixia Zou, hanshuo Yang, Yuquan Wei, Junming Quan, Hui Zhang, Zhen Yang,* Shuo Lin* “Identifying Tumor Cell Growth Inhibitors by Combinatorial Chemistry and Zebrafish Assays” PLoS ONE20094(2), e4361.
    9.  Chao Che, Jing Xiang, Guoxin Wang, Reza Fathi, Junmin Quan, Zhen Yang* “A One-Pot Synthesis of Functionalized Quinoline-based Poly-Heterocycles by a Tandem Three-Component Reaction” J. Comb. Chem. 2007, 9, 982-989.
    10.  Chao Che, Zhongning Zhang* “Concise Total Synthesis of (3Z, 6Z, 9S, 10R)-9, 10-Epoxy-1, 3, 6-Heneicosatriene, Sex Pheromone Component of Hyphantria cunea.” Tetrahedron200561, 2187-2193.