Fan Jiang
  • Education & Experience
    2012 – 2015        Senior Research Associate, Peking University Shenzhen Graduate School
    2010 – 2012        Post Doctor Fellow, Peking University Shenzhen Graduate School
    2008 – 2010        Visiting Scholar, the Hong Kong University of Science and Technology
    2003 – 2008        Ph.D. in Physical Chemistry, Peking University
    1999 – 2003        B. Sc. in Chemistry, Peking University
  • Awards & Honors
    1999        Outstanding Freshman Award, Peking University
    2006        Dong-Gang Scholarship, Peking University
    2008        Thomson-Reuters Research Fronts Award
  • Research Fields
    One key challenge towards the deciphering of the genetic information encoding various biological phenomena is to predict the 3D structures of biological molecular systems (peptides, proteins, RNA, and various complexes) from their sequences. We want to develop more accurate computational approaches for this structure prediction problem, by combining a variety of methods from different research fields: (1) first-principle calculation using quantum mechanics, (2) molecular dynamics simulation based on statistical physics, (3) data mining of experimental structures, (4) analysis of evolutionary or physicochemical similarity of sequences and their co-evolutions, and (5) genetic algorithms and various machine learning methods.
  • Selected Publications
    1.  Xun, S.; Jiang, F.;* Wu, Y.-D.* Significant refinement of protein structure models using a residue-specific force field. J. Chem. Theory Comput. 2015, 11, 1949–1956 
    2.  Zhou, C.-Y.; Jiang, F.;* Wu, Y.-D.* Residue-specific force field based on protein coil library. RSFF2: modification of Amber ff99SB. J. Phys. Chem. B 2015, 119, 1035–1047.
    3.  Jiang, F.;* Wu, Y.-D.* Folding of fourteen small proteins with a residue-specific force field and replica-exchange molecular dynamics. J. Am. Chem. Soc. 2014, 136, 9536–9539.
    4.  Jiang, F.;* Zhou, C.-Y.; Wu, Y.-D.* Residue-specific force field based on the protein coil library. RSFF1: modification of OPLS-AA/L. J. Phys. Chem. B 2014, 118, 6983–6998. (Invited feature article with cover art)
    5.  Jiang, F.; Han, W.; Wu, Y.-D. The intrinsic conformational features of amino acids from a protein coil library and their applications in force field development. Phys. Chem. Chem. Phys. 2013, 15, 3413–3428. (Perspective article)
    6.  Wang, Y.; Jiang, F.; Zhuo, Z.; Wu, X.; Wu, Y.-D. A method for WD40 repeat detection and secondary structure prediction. Plos One 2013, 8, e65705.
    7.  Jiang, F.; Han, W.; Wu, Y.-D. Influence of side chain conformations on local conformational features of amino acids and implication for force field development. J. Phys. Chem. B. 2010, 114, 5840–5850.
    8.  Tang, Z.;† Jiang, F.;† Cui, X.; Gong, L. Z.; Mi, A. Q.; Jiang, Y. Z.; Wu, Y.-D. Enantioselective direct aldol reactions catalyzed by L-prolinamide derivatives. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5755–5760. (†co-first author)