Olaf Wiest
  • Olaf Wiest

  • 职务:课题组长,教授
  • 电话:+86-755-2603-7219
  • 邮箱:owiest@nd.edu
  • 课题组主页:http://web.pkusz.edu.cn/wu/
  • 教育背景及工作经历
    2013 –           Visiting Professor, Dana Farber Cancer Institute, Harvard Medical School  
    2011 -           Visiting Professor, PKUSZ
    2010 - 2012    Adjunct Professor, HKUST
    2007, 2009     Visiting Professor, HKUST
    2007              Visiting Professor, University of California, San Francisco
    2005 -            Professor of Chemistry and Biochemistry, University of Notre Dame
    2001 - 2005    Associate Professor of Chemistry and Biochemistry, University of Notre Dame
    2000 -            Consultant to pharmaceutical industry
    1999 -            Founding Member, Walther Cancer Research Center
    1996 - 2001    Assistant Professor of Chemistry and Biochemistry, University of Notre Dame
    1993 - 1995    Postdoctoral Fellow with Prof. Dr. K. N. Houk, UCLA
    1991 - 1993    Dr. rer. nat. (Ph.D.), with Prof. Dr. E. Steckhan, University of Bonn (Germany)
    1990 - 1991    Diplom (M.S.), with Prof. Dr. E. Steckhan University of Bonn (Germany)
  • 奖项及荣誉
    2012              Elected Fellow of the American Association for the Advancement of Science
    2004              Kaneb Teaching Award
    2001 – 2006   Camille Dreyfus Teacher-Scholar Award
    1998 – 2003   National Institutes of Health FIRST Award
    1997 – 2002   National Science Foundation CAREER Award
    1993 - 1995    Feodor Lynen-Fellowship of the Alexander von Humboldt-Foundation
    1990 - 1991    Richard-Winther Fellowship
  • 研究兴趣
    Computer Aided Drug Design: Virtual Screening;
    Computational Enzymology; Cheminformatics; QSAR
    Epigenetic Control of Gene Expression in Cancer: HDACs and Bromodomains
    Small-Molecule Treatments of Metabolic and Neurodegenerative Diseases, especially Niemann Pick Type C
    Systems Biology Approaches to Antibiotic Drug Discovery (Staph. aureus) and to rare diseases
    Organic and Metalorganic Reaction Mechanism, especially prediction of stereoselectivity
    Entrepreneurship in Drug Discovery & Chemical Biology
  • 代表性成果
    1. K. Chen, L. Xu, O. Wiest “Zinc Binding Groups for HDAC Inhibition”  J. Org. Chem. 2013, 78, 5051–5055
    2. B. E. Haines, C. N. Steussy, C. V. Stauffacher, O. Wiest “Molecular Modeling of the Reaction Pathway and Hydride Transfer Reactions of HMG-CoA Reductase” Biochemistry, 2012, 51, 7983-7995
    3. J. Lee, P. Helquist, O. Wiest “Diastereoselectivity in Lewis-Acid-Catalyzed Mukaiyama Aldol Reactions: A DFT Study” J. Am. Chem. Soc. 2012, 134, 14973–14981
    4. O. Wiest, P. Helquist “Striking a Balance to Control Stereochemistry” Science 2011, 333, 1831-1832
    5. H. Pipalia, C. C. Cosner, A. Huang, A. Chaterjee, P. Bourbon, N. Farley, P. Helquist, O. Wiest, F. R. Maxfield “Histone deacetylase (HDAC) inhibitor treatment dramatically reduces cholesterol accumulation in lysosomal storage organelles of Niemann-Pick Type C1 human fibroblasts” Proc. Natl. Acad. Sci. 2011, 108, 5620-5625
    6. Y. Shen, J. Liu, G. Estiu, B. Isin, D-S. Lee, A-L. Barabási, V. Kapatral, O. Wiest, Z. N. Oltvai “A blueprint for antimicrobial hit discovery targeting metabolic networks” Proc. Natl. Acad. Sci. 2010, 107, 1082-1087
    7. P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W. B. Smith, O. Fedorov, E. M. Morse, T. Keates, T. T. Hickman, I. Felletar, M. Philpott, S. Munro, N. West, M. J. Cameron, T. Heightman, N. LaThangue, A. Kung, C. A. French, O. Wiest, S. Knapp, J. E. Bradner “Selective Inhibition of BET Bromodomains” Nature 2010, 468, 1067-1073
     
    PATENTS
    US Patent Application No. 12/888,267
    US Patent Application No. 13/490,693