霍玉庆
  • 霍玉庆

  • 职务:教授, 新药研发中心共同主任
  • 电话:+86-755-2153-9221
  • 邮箱: huoyq@pkusz.edu.cn, yhuo@gru.edu
  • 课题组主页:http://web.pkusz.edu.cn/huoyq/
  • 教育背景及工作经历
    2012 -                 北京大学深圳研究生院,教授
    2012 -                 美国佐治亚医学院,教授,血管与炎症项目主任
    2004 - 2011        美国明尼苏达大学,助理教授/副教授(终生教职)
    2001 - 2004        美国弗吉尼亚大学,研究助理教授
    1998 - 2001        美国弗吉尼亚大学,博士后
    1995 - 1998        北京大学,医学博士
    1992 - 1995        青岛大学,医学硕士
    1985 - 1989        济宁医学院,医学学士
  • 奖项及荣誉
    2008                 Finalist of Irvine H. Page young investigator research award from the        
                             arteriosclerosis, thrombosis, and vascular biology annual Conference 2008 (Atlanta, Georgia, USA). 
    2006                 Nominee of the Institute of Medicine Anniversary Fellow from the Medical
                             School of University of Minnesota (July, 2006), USA.
    2004-2006        Scientist Development Award (National level) from American Heart Association, USA. 
    2004-2007        Lillehei Scholar Award from Lillehei Heart Institute at the University of Minnesota, USA.
    2004-2006        Atorvastatin Research Award from Pfizer, Inc., USA.     
    2002                 Young Investigator Award from the Cardiovascular Section of American Physiological Society (April 21),                                USA. 
    2001-2003        Postdoctoral Fellowship Award (2001-2003) from American Heart Association,
                             USA.
    2001                 New Investigator Award from American Heart Association on May 11, 2001,
                             USA.
  • 研究兴趣

           本课题组探讨血液细胞,包括白细胞、红细胞、血小板在炎症相关疾病,如动脉粥样硬化、血栓形成、糖尿病、肥胖等疾病的功能作用。在生理及以上病理条件下使用在体成像技术观察血液细胞及其碎片与血管内皮细胞的相互作用的差别,分析在使用封闭抗体或基因敲除后抑制其相互作用可否发挥治疗性作用。课题组亦致力于探讨代谢途径对代谢疾病、心血管、肿瘤及相关疾病的影响。目前集中于糖及能量代谢,嘌呤、嘧啶等核苷酸代谢对信号转导、炎症、血管功能及在相关疾病如炎症、败血症、动脉硬化、糖尿病、肥胖、肿瘤及其他疾病中的作用。这些研究将为探索治疗以上相关疾病提供新的途径。

  • 代表性成果
    1. Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y. Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014, 34(6):1231-9. 
    2. Wei S, Wang H, Zhang G, Lu Y, An X, Ren S, Wang Y, Chen Y, White JG, Zhang C, Simon DI, Wu C, Li Z, Huo Y. Platelet IκB kinase-β deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibα shedding. Arterioscler Thromb Vasc Biol. 2013, 33(2):241-8.
    3. Huo Y, Guo X, Li H, Xu H, Halim V, Zhang W, Wang H, Fan YY, Ong KT, Woo SL, Chapkin RS, Mashek DG, Chen Y, Dong H, Lu F, Wei L, Wu C. Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses. J Biol Chem. 2012, 287(25): 21492-500.
    4. Wang H, Zhang W, Tang R, Zhu C, Bucher C, Blazar B, Geng J, Zhang C, Linden J, Wu C, Huo Y.  Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2010, 30(5): 915-22.
    5. Zhang W, Wang J, Wang H, Tang R, Belcher JD, Viollet B, Geng JG, Zhang C, Wu C, Slungaard A, Zhu C, Huo Y. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol. 2010, 30(5): 1000-6.
    6. Wang H, Zhang W, Zhu C, Bucher C, Blazar B, Zhang C, Chen J, Linden J, Wu C, Huo Y. Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis. Arterioscler Thromb Vasc Biol. 2009, 29(7): 1046-52.
    7. Wang H, Zhang W, Tang R, Hebbel RP, Kowalska MA, Zhang C, Marth JD, Minoru F, Zhu C and Huo Y. Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in apoE-deficient mice. Arterioscler Thromb Vasc Biol. 2009, 29(7): 1053-9.
    8. An G, Wang H, Tang R, Yago T, McDaniel M, McGee S, Huo Y, Xia L.. PSGL-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 2008, 117: 3227-37. 
    9. Huo Y, Zhao L, Hyman M,Shashkin P, Harry B, Burcin T, Forlow B, Stark M, Smith D, Clarke S, Srinivasan S, Hedrick CC, Pratico D, Witztum JL, Nadler JL, Funk CD, Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004, 110: 2024-31. 
    10. Huo Y, Forlow B, Schober A, Smith D, Hyman M, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in apoE-/- mice. Nature Medicine 2003, 9: 61-67. 
    11.  Huo Y, Weber C, Forlow B, Sperandio M, Lung S, Littman DR, Ley K. The chemokine KC and RANTES, but not MCP-1 arrest monocyte on native early atherosclerotic endothelium. Journal of Clinical Investigation 2001, 108: 1307-1314.