洪梅
  • 洪梅

  • 职务:课题组副组长,副研究员
  • 电话:+86-755-2153-9221
  • 邮箱:meihong@pkusz.edu.cn
  • 课题组主页:http://web.pkusz.edu.cn/huoyq/
  • 教育背景及工作经历
    教育背景
    2005- 2008        北京大学医学部,生物化学与分子生物学系,尚永丰院士实验室,博士后
    2000- 2005        日本富山医科药科大学,生物化学和病理学联合培养,医学博士,导师:许南浩教授、高野康雄教授,
    1992-1997         北京医科大学,临床医学专业,医学学士
    工作经历
    2015-至今          北京大学深圳研究生院,化学生物学与生物技术学院,副研究员
    2012-2015         兰州大学第二医院泌尿外科研究所,甘肃省泌尿系疾病研究重点实验室,助理研究员
    1997-2000         北京大学人民医院,内科,住院医师
  • 奖项及荣誉
    2014                  国家自然科学基金青年基金,甘肃省科技计划
    2000-2005        日本文部省奖学金
  • 研究兴趣
    心脑血管相关疾病及代谢相关疾病
    肿瘤相关基因、信号通路及生物治疗
    转录调控及mRNA降解调控
  • 代表性成果
    1. Yi X, Hong M, Gui B, Chen Z, Li L, Xie G, Liang J, Wang X, Shang Y*. The RNA processing and modification protein, carbon catabolite repression 4, arrests the cell cycle through a p21-dependent and p53-independent pathway. J Biol Chem 2012; Apr 30. 287(25):21045-57.
    2. Shi B, Liang J, Yang X, Wang Y, Zhao Y, Wu H, Sun L, Zhang Y, Chen Y, Li R, Zhang Y, Hong M, Shang Y*. Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells. Mol Cell Biol 2007; 27(14):5105-19.
    3. Abdel-Aziz HO, Murai Y, Hong M, Kutsuna T, Takahashi H, Nomoto K, Murata S, Tsuneyama K, Takano Y*. Detection of the JC virus genome in lung cancers: possible role of the T-antigen in lung oncogenesis. Appl Immunohistochem Mol Morphol 2007;15(4):394-400.
    4. Murai Y, Zheng HC, Aziz HO, Hong M, Kutsuna T, Nakanishi Y, Tsuneyama K, Takano Y*. High JC virus load in gastric cancer and adjacent non-cancerous mucosa. Cancer Sci 2007; 98(1):25-31.
    5. Zheng H, Murai Y, Hong M, Nakanishi Y, Nomoto K, Masuda S, Tsuneyama K, Takano Y*. JC virus detection in the human tissue specimens. J Clin Pathol 2007; 60(7):787-93.
    6. Hong M, Murai Y, Kutsuna T, Takahashi H, Nomoto K, Cheng CM, Ishizawa S, Zhao QL, Ogawa R, Harmon BV, Tsuneyama K, Takano Y*. Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells. J Cancer Res Clin Oncol 2006; 132(1):1-8.
    7. Nakajima A, Kataoka K, Hong M, Sakaguchi M, Huh NH*. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett 2003; 201(2):195-201.
    8. Mei Hong, Ping Zhang, Shengjun Fu, Jianzhong Lu, Hanzhang Wang, Zhiping Wang*. FOXO3a-ROS pathway is involved in androgen-induced proliferation and mobility of prostate cancer cells. (submitted)
    9. Mei Hong, Jinxia Zhao, Qi Guo, Baoliang Ma, Gongjian Zhu, Zhiping Wang*. Downregulation of BTG2 is frequent in human bladder cancer and overexpression of BTG2 suppressed proliferation of bladder cancer EJ cells. (manuscript in preparation)
    10. Qingyan Li, Mei Hong (Co-first author), Qingying Zhang, Hong Liang, Yuying Zhao*. Identification of Novel Compounds, upregulating PPARγ and stimulating glucose consumption, from Momordica charantia L. (manuscript in preparation)