李 松
  • 李 松

  • 职务:副课题组长,副教授
  • 电话:+86-755-2603-2163
  • 邮箱:lisong@pkusz.edu.cn
  • 课题组主页:http://web.pkusz.edu.cn/lin
  • 教育背景及工作经历

    2006 –               副教授,北京大学深圳研究生院
    2003–2006        副研究科学家,人类病毒学研究所,马里兰大学,巴尔的摩,美国
    1999–2003        博士,日本山形大学医学院
    1995–1999        区经理,葛兰素史克制药公司
    1993 –1995       医师,沈阳市中心医院
    1988–1993        本科,沈阳医科大学

  • 奖项及荣誉

    2000        日本教育行政基金会奖学金

  • 研究兴趣

    转基因斑马鱼药物筛选

  • 代表性成果

    1. Chen, P.Y., Li, S., Liu, L., Xu, N.,”Long-term effects of binary mixtures of 17α-ethynylestradiol (EE2) and dibutyl phthalate (DBP) in a partial life-cycle test with zebrafish (Danio rerio)”Environmental Toxicology & Chemistry. 2015, 34(3): 518-526.
    2. Wei Qin, Zelin Chen,Yihan Zhang, Ruibin Yan,Guanrong Yan,Song Li,Hanbing Zhong, and Shuo Lin.,” Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish” PLoS One.2014,9(6):e100796.
    3. Xu, N.,  Chen, P.Y., Liu, L., Zeng, Y.Q., Zhou, H.X., Li, S. ,”Effects of combined exposure to 1
    7α-ethynylestradiol and dibutyl phthalate on the growth and reproduction of adult male zebrafish (Danio rerio)”Ecotoxicology and Environmental Safety. 2014,107: 61-70.
    4. ChaoCheBo YangXianlong JiangTaofeng ShaoZhixiong YuChuanye TaoSong LiShuoLin.,” Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-annulation” The Journal of organic chemistry.2014,79(1): 436-440.
    5. Guiqi Ren, Song Li, Hanbing Zhong and Shuo.,”Encodes Tryptophan Hydroxylase Zebrafish tyrosine hydroxylase 2 Gene” J. Biol. Chem. 2013, 288:22451-22459.
    6. Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S.,”A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay”  PLoS One. 2013,26;8(4):e53317.
    7. Che C., Li S., Yu Z. X., Li F. F., Xin S. C., Zhou L. Y., Lin S., Yang, Z., “One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy”ACS Combinatorial Science.2013, 15 (4):202-207.
    8. Xin SC, Zhao YQ, Li S, Lin S, Zhong HB,"Application of zebrafish models in drug screening"Yi Chuan. 2012, 34(9):1144-52.
    9. Yike YuanYuwei ZhaoShengchang XinNi WuJiaolin WenSong LLijuan ChenYuquan WeHanshuo YangShuo Lin.,” A Novel PEGylated Liposome-Encapsulated SANT75Suppresses Tumor Growth through Inhibiting HedgehogSignaling Pathway” PLoS One.2013,8(4):e60266.
    10. Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu,Taofeng Shao, Chuanye Tao, Shuo Lin, and Zhe.,” Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors” Beilstein J. Org. Chem..2012,8: 841-849.
    11. Liangliang Xu, Wenguang Yin, Jianhong Xia,Meixiu Peng,Song Li,Shuo Lin,Duanqing Pei,and Xiaodong Shu.,” An Antiapoptotic Role of Sorting Nexin 7 Is Required for Liver Development in Zebrafish””HEPATOLOGY 2012;55:1985-1993.
    12. Lu Chen, Xi Ren, Fang Liang, Song Li, Hanbing Zhong, Shuo Lin.,“ Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis” Pigment Cell & Melanoma Research.2012,25(4):446–453.
    13. Guiqi Ren, Shengchang Xin, Song Li, Hanbing Zhong, Shuo Lin.,” Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish” PLoS one.2011,6(6) :e20630.
    14. Hanbing Zhong, Danyang Wang, Nan Wang, Yesenia Rios, Haigen Huang, Song Li, Xinrong Wu,Shuo Lin.,” Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity” Cell Research.2011,4(1):1080-1087.
    15. Chao Che, Song Li, Xianlong Jiang, Junmin Quan, Shuo Lin, and Zhen Yang.,” One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” ORGANIC LETTERS.2010,12(20):4682-4685.
    16. Yanqun Chen, Bin Wu, Liangliang Xu, Huapeng Li, Jianhong Xia, Wenguang Yin, Zhuo Li, Song Li, Shuo Lin, Xiaodong Shu and Duanqing Pei.,”A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo”Cell Research , 2012, 22(2)” 333-345.
    17. Hanbing Zhong, Shengchang Xin, Yanqiu Zhao , Jing Lu , Song Li, Jianxian Gong, Zhen Yang and Shuo.,” Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish” Molecular BioSystems.2010,6(8):1463-8.
    18. Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin.,” Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling” Molecular BioSystems.2009,11(5):1356-1360.
    19. Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman, Song Li, Jin Jiang, James K. Chen, Zhen Yang, Shuo Lin.,” Converse conformational control of smoothened activity by structurally related small molecules” JOURNAL OF BIOLOGICAL CHEMISTRY.2009,284(31):20876-884.
    20. Song Li, Luisa Bozzo, Zhibin Wu, Wuyuan Lu, Fabio Romerio. The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells. New Microbiological, 201033:13-24.
    21. Susa, S, Daimon M, Ono H, Li S, Yoshida T, Kato T. The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria. Tohoku J Exp Med. 2003 200:39-45.
    22. Susa, S.; Daimon, M.; Ono, H.; Li, S.; Yoshida, T.; Kato, T. Heme inhibits the mitochondrial import of coproporphyrinogen oxidase. Blood. 2002100: 4678-9.