邓宏魁
  • 邓宏魁

  • 职务:课题组长,教授,“长江学者”特聘教授
  • 电话:+86-10-6275-6474
  • 邮箱: hongkui_deng@pku.edu.cn
  • 课题组主页:http://web.pkusz.edu.cn/deng
  • 教育背景及工作经历

    2001—至今         北京大学细胞生物学,教授
    1998—2001        美国麻省Viacell Inc. 公司,分子生物学主任
    1995—1998        美国纽约大学医学中心Aaron Diamond研究中心,博士后
    1990—1995        美国加州大学洛杉矶分校,博士
    1980—1984        武汉大学生物学系,理学学士

  • 奖项及荣誉

    1995        Aaron Diamond Fellowship
    2001        国家杰出青年科学基金
    2005        Bill and Melinda Gates Foundation Grand Challenge Grant
    2006        Lilly-Asian Scientific Excellence Award
    2010        Sanofi-aventis / Cell Research Outstanding Paper Award
    2011        北京市科学技术一等奖
    2011        中华医学科技奖,二等奖
    2013        药明康德生命化学研究杰出成就奖
    2014        谈家桢生命科学奖

  • 研究兴趣

    1. 细胞重编程
    2. 干细胞与再生医学
    3. 干细胞工程
    Figure: Direct differentiation of human embryonic stem cell into functional hepatic cells (A) and pancreatic beta cells (B).

  • 代表性成果

    1.  Fang R, Liu K, Zhao Y, Li H, Zhu D, Du Y, Xiang C, Li X, Liu H, Miao Z, Zhang X, Shi Y, Yang W, Xu J, Deng H. “Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts.” Cell Stem Cell.2014, 15(4):488-96.
     2.  Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell2014 ;14:394-403.
     3.  Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013, 341(6146):651-4.
     4.  Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W,Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H. “Induction of pluripotency in mouse somatic cells with lineage specifiers.”Cell. 2013, 153(5):963-75.
     5.  Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H. “Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo.”Cell Stem Cell. 2013, in press.
     6.  Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S. “Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors.” Cell Stem Cell. 2009,4(1):16-19.
     7.  Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H. “Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.“ Cell Stem Cell. 2008, 3(6):587-590.
     8.  Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. “Two supporting factors greatly improve the efficiency of human iPSC generation.” Cell Stem Cell. 20083(5):475-479.
     9.  Deng, H, Unutmaz, D, Kewalramani, V, and Littman, D. “Expression cloning of novel coreceptors utilized by the simion and human immunodeficencyviruses.”Nature. 1997. 388:296-300
     10.  Deng, H, Liu, R, Ellmeier, W, Choe, S, Untmaz, D, Burkhart, M, Marazio, P, Marmon, S, Sutton, R, Hill, C, Davis, C, Peiper, S, Schall, T, Littman, Dand Landau, N.“Identification of a major co-receptor for primary isolates HIV-1.”Nature. 1996. 381:661-666.