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Education & Experience
2015 – Present Associate Professor with Tenure, PKUSZ
2006 – 2014 Associate Professor, Peking University, Shenzhen Graduate School
2004 – 2006 Postdoctoral Fellow, Peking University, Shenzhen Graduate School
2000 – 2004 Ph. D. Hong Kong University of Science & Technology
1997 – 2000 M.Sc., Sun Yat-Sen University
1993 – 1997 B.Sc., Peking University
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Awards & Honors
2010 The Hundred Talents Program of Peking University
2008 Shenzhen Shuangbai Project
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Research Fields
Our research efforts have focused on protein-protein interactions in signaling pathways involved in cell fate regulations such as proliferation, differentiation, and cell death. Using an interdisciplinary strategy combining theoretical and experimental approaches, we wish to crack the molecular basis underlying protein-protein interactions in these important biological processes, and design novel inhibitors to modulate the characterized protein-protein interactions.
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Selected Publications
1. Chen Shen, Hong Yue, Jianwen Pei, Xiaomin Guo, Tao Wang*, Junmin Quan* “Crystal structure of the death effector domains of caspase-8” BBRC, 2015, 463, 297–302.
2. Hong Yue, Feng Lu, Chen Shen, Junmin Quan* “Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway” Bioorg. Chem. 2015, 61, 21–27.
3. Hongmei Shan, Yanxia Shi, Junmin Quan*. “Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1” ChemMedChem. 2015, 10, 158-163.
4. Hongmei Shan, Tao Wang*, Junmin Quan*. “Crystal structure of the Polo-box Domains of Polo-like Kinase 2” BBRC, 2015, 456, 780–784.
5. Jun Xu, Chen Shen, Tao Wang*, Junmin Quan* “Structural basis for the inhibition of Polo-like kinase 1” Nat. Struct. Mol. Biol. 2013, 20, 1047-53. (Highlighted in cover and also by Nature China, 2 October 2013 | doi:10.1038/nchina.2013.92)
6. Dai L, Liu Y, Liu J, Wen X, Xu Z, Wang Z, Sun H, Tang S, Maguire AR, Quan J*, Zhang H*, Ye T*. “A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy.” Cancer Lett. 2013, 333, 103-112.
7. Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan*, Tao Ye*, Hui Zhang*. “Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties” Cancer Res. 2011, 71, 7238-49. (Highlighted by Nature China, 4 January 2012 | doi:10.1038/nchina.2012.1)
8. Xiaolei Wang, Junmin Quan* “Intermediate-Assisted Multifunctional Catalysis in the Conversion of Flavin to 5,6-Dimethylbenzimidazole by BluB: A Density Functional Theory Study” J.Am. Chem. Soc. 2011, 133, 4079-4091.
9. Lintai Da, Junmin Quan*, YunDong Wu* “Understanding the binding mode and function of BMS-488043 against HIV-1 viral entry” Proteins: Struct., Funct., Bioinf. 2011, 79, 1810-1819.
10. Haixia Zou, Liyan Zhou, Yuanzhen Li, Hanbing Zhong, Zhengying Pan, Zhen Yang, Junmin Quan* “Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype” J. Med. Chem. 2010, 53, 994-1003.
