在最近一期的Molecular Biosystems杂志上，化学生物学与生物技术学院的林硕、杨震和仲寒冰三个课题组合作发表了一篇论文《Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling》。这篇论文中，作者首先采用斑马鱼模型筛选到了一个小分子GSK3抑制剂，随后用有机合成方法进一步改造这个抑制剂，最终得到一类具有新骨架的抑制剂，并研究了这些抑制剂在胚胎发育中的作用。论文信息见下。

On the latest issue of Molecular Biosystems, three groups (Dr. Lin, Dr. Yang and Dr. Zhong) in School of Chemical Biology and Biotechnology published a paper titled “Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling”. In this paper, the authors employed zebrafish as a model to screen chemical libraries and identified a small-molecule GSK3 inhibitor, which was further modified by organic synthesis approaches to create new generation GSK3 inhibitors with novel scaffold. The information of the paper is below.

Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling
Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin,  Mol. BioSyst., 2009, 5, 1356

2009-10-26