各位老师和同学，大家好，

我院邀请了John F Hartwig 教授将于2024年9月26日（星期四）C105教室进行南燕大讲堂第103讲讲座报告，欢迎大家参加！

讲座题目：酶的定向进化和细胞内人工生物合成

Laboratory Chemistry in a Protein within a Cell for Artificial Biosynthesis

主讲人：John F Hartwig，University of California at Berkeley，Wolf Prize in Chemistry（2019），Arthur C Cope Award (2021)

时间：9月26 日（星期四）15:30-17:00 pm

讲座地点: C栋105

主持人：周建荣

讲座摘要：

This talk will include results on new transformations, new mechanisms, new reactive intermediates, and new methods for in vivo assembly of artificial metalloenzymes. This combination of results has enabled us to combine an unnatural carbene-transfer reaction catalyzed by natural and artificial metalloenzymes with the biosynthesis of diazo compounds and natural reactions of a heterologous biosynthetic pathway to create engineered microorganisms that produce unnatural products by artificial biosynthesis encompassing organometallic chemistry.

嘉宾简介：

John F. Hartwig is Henry Rapoport Chair Professor in Organic Chemistry, University of California at Berkeley. Professor Hartwig's research focuses on the discovery and understanding of new reactions catalyzed by transition metal complexes. He has developed a selective catalytic functionalization of alkanes,a method for formation of arylamines and aryl ethers from aryl halides or sulfonates,a method for the direct conversion of carbonyl compounds to alpha-aryl carbonyl derivatives, a system for the catalytic addition of amines to vinylarenes and dienes, and highly selective catalysts for the regio and enantioselective amination of allylic carbonates.

With each system, his group has conducted extensive mechanistic investigations. He has revealed several new classes of reductive eliminations, has isolated discrete compounds that functionalize alkanes, and has reported unusual three-coordinate arylpalladium complexes that are intermediates in cross coupling. During the past several years, his group also has developed, in collaboration with his colleague Prof. Doug Clark, artificial metalloenzymes in which the native metal is replaced by an organometallic fragment to enable abiotic reactivity.

请注意： 本次讲座需要化学、生物方向学生签到！