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教育背景及工作经历
2020.05-至今 深圳湾实验室 特聘研究员,课题组长
2019.01-至今 北京大学深圳研究生院 特聘研究员,博士生导师
2017.09-2018.12 斯坦福大学 基础研究科学家
2011.09-2017.08 斯坦福大学/霍华德休斯研究所 博士后
2005.09-2011.07 北京大学 博士
2001.09-2005.07 中央民族大学 学士
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奖项及荣誉
2023 深圳市政府特殊津贴专家
2022 深圳市光明区改革创新先进个人
2020 国家自然科学基金委优秀青年项目(国家优青)
2019 广东省珠江人才计划-引进青年拔尖人才
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研究兴趣
神经突触的形成和维持功能的分子基础,以及神经突触结构/功能障碍在神经和精神疾病中作用机理。
发表文章(#:共同第一;*:共同通讯)
1: Qin, L*, Liu, Z.*, Guo, S., Han, Y., Wang, X., Ren, W., Chen, J., Zhen, H., Nie, C., Xing, K., Chen, T., Südhof TC*, Sun, Y. *, Zhang, B*. (2024). Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02659-6(最后通讯作者)
2: Lloyd, B.A., Han, Y., Roth, R., Zhang, B., Aoto, J*. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature Communications. 14, 4706. https://doi.org/10.1038/s41467-023-40419-2
3: Zhu, F. #, Liu, L. #, Li, J. #, Liu, B., Wang, Q., Jiao R., Xu, Y., Wang, L., Sun, S., Sun, X., Younus, M., Wang, C., Hokfel, T., Zhang, B.*, Gu, H. *, Xu, Z. *, Zhou, Z. *. (2022). Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Reports. 40(7), 16 August 2022, 111199. https://doi.org/10.1016/j.celrep.2022.111199 (共同通讯作者)
4: Han, Y#, Cao, R#, Qin, L., Chen, L., Tang, A., *, Südhof, TC*, Zhang, B*. (2022) Neuroligin-3 confines AMPA-receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses. Science Advances. 8(24):eabo4173. https://www.science.org/doi/10.1126/sciadv.abo4173 (最后通讯作者)
5: Qin, L., Guo, S., Han, Y., Wang, X., Zhang, B*. (2020) Functional mosaic organization of neuroligins in neuronal circuits. Cellular and Molecular Life Sciences. 77, 3117-3127. https://doi.org/10.1007/s00018-020-03478-y (最后通讯作者)
6: Zhang, B.*,Gokce, O., Hale, D., Brose, N., Südhof, TC. (2018) Autism-associated Neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses. Journal of Experimental Medicine. 215 (6): 1543-1553 (唯一通讯作者)
7: Zhang, B.*,Seigneur, E., Wei, P., Gokce, O., Morgan, J., Südhof, TC. (2017) Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held. Molecular Psychiatry. 22, 1483–1491. [F1000 recommended] (唯一通讯作者)
8: Zhang, B.*, Südhof, TC. (2016). Neuroligins are selectively essential for NMDA-receptor signaling in cerebellar stellate interneurons. J. Neurosci. 36(35):9070-9083. [F1000 recommended]. (唯一通讯作者)
9: Zhang, B.#, Chen, L. #, Maxeiner, S., Lee, S., Gokce, O., Südhof, TC*. (2015) Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 87(4):781-96. [Cover Story]