师资队伍

2009－2010 哈佛大学，化学与化学生物学系博士后

2004－2008 芝加哥大学，化学系博士

2001－2004 杜兰大学，化学系硕士

1996－2001 中国科学技术大学，神经科学和生物物理系学士

2017 拜耳学者奖

2013 深圳市杰出青年基金奖

2012 深圳市高层次人才

2010 美国国家癌症中心博士后奖金

2008 芝加哥大学Harper毕业论文奖

我们的研究小组将在化学和生物交叉领域用化学方法解决生物学问题。我们的研究领域主要包括稳定多肽二级结构的方法学研究、治疗性靶点研究、微生物毒力及抗感染治疗研究和多肽自组装材料研究等四个方面。

1) 稳定多肽二级结构的方法学研究

蛋白-蛋白相互作用 (PPIs) 通常被视为药物发现的非药物性靶点，大多数PPIs包括少于15个氨基酸残基的短螺旋多肽，通过化学手段将多肽稳定在某一固定构象的稳定多肽是重要的调节PPI的代表性化合物。我们课题组的相关研究关注多肽工程战略，致力于发展新型多肽螺旋构象稳定方法，以解释稳定多肽的二级构象对其生物物理性能的影响。与此同时我们通过化学稳定的多肽来研究重要蛋白靶点的生物功能和作用机制，为探索更加有效的药物前体奠定基础。

1) Dan, Y. et. al. “Development of a high quantum yield dye for tumor imaging”Chemical Science2017(Accepted)

2) Yin, F.; Hu, K.; Chen Y.; Yu, M.; Wang, D.; Wang, Q.; Yong, K. T.; Lu, F.; Liang, Y.; Li, Z. “SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer”Theranostics.2017,7, 1133.

3) Zheng, W.; Cai, X.; Xie, M.; Liang, Y.; Wang, T.; Li, Z. “Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus”Cell Chemical Biology2016,23, 1002.

4) Zhao, H.; Liu, Q. S.; Geng, H.; Tian, Y.; Cheng, M.; Jiang, Y. H.; Xie, M. S.; Niu, X. G.; Jiang, F.; Zhang, Y. O.; Lao, Y. Z.; Wu, Y. D.; Xu, N. H.; Li, Z. “Crosslinked Aspartic Acids as Helix-Nucleating Templates”Angew. Chem. Int. Ed.2016,55, 12088.

5) Yuan, F.; Deng, Y. Y.; Zhou, W. Y.; Zhang, M.; Li, Z. “A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field-effect transistors”Nano Research2016,9, 1701.

6) Tian, Y.; Li, J. X.; Zhao, H.; Zeng, X. Z.; Wang, D. Y.; Liu, Q. S.; Niu, X. G.; Huang, X. H.; Xu, N. H.; Li, Z. “Stapling of unprotected helical peptides via photoinduced intramolecular thiol-yne hydrothiolation”Chemical Science2016, 7, 3325.

7) Hu, K.; Geng, H.; Zhang, Q.; Liu, Q.; Xie, M.; Sun, C.; Li, W.; Lin, H.; Jiang, F.; Wang, T.; Wu, Y. D.; Li, Z. “An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide”Angew. Chem. Int. Ed.2016,55, 8013.

8) Zhang, Q. Z.; Jiang, F.; Zhao, B. C.; Lin, H. C.; Tian, Y.; Xie, M. S.; Bai, G. Y.; Gilbert, A. M.; Goetz, G. H.; Liras, S.; Mathiowetz, A. A.; Price, D. A.; Song, K.; Tu, M. H.; Wu, Y. J.; Wang, T.; Flanagan, M. E.; Wu, Y. D.; Li, Z. G. “Chiral Sulfoxide-Induced Single Turn Peptide alpha-Helicity”Scientific Reports2016,6, 38573.

9) Zhao, W.; Qian, H.; Li, Z.; Sun, J. “Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams”Angew. Chem. Int. Ed.2015,54, 10005.

10) Zhao, W.; Li, Z.; Sun. J. “A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition”J. Am. Chem. Soc.2013,135, 4680.

11) Cai, S.; Zhao, X.; Wang, X.; Liu, Q.; Li, Z.; Wang, D. Z.; “Visible-light-promoted C-C bond cleavage: photocatalytic generation of iminium ions and amino radicals”Angew. Chem. Int. Ed.2012,51, 8050.

12) Yang, S. D.; Li, Z.; Han, X.; He, C. “Platinum (II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp(3) C-H Activation”Angew. Chem. Int. Ed.2009,48, 3999.

13) Li, Z.; Brouwer, C; He, C. “Gold-catalyzed organic transformations”Chemical Reviews2008,108, 3239.

14) Chen, H.; Hu, J.; Chen, P. R.; Lan, L. F.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C. “The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism”Proc. Natl. Acad. Sci.2008,105, 13586.

15) Chang, S.; Bray, S.M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. “Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila”Nature Chemical Biology2008,4, 256.

16) Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups”J. Am. Chem. Soc.2007,129, 12058.

17) Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Silver-catalyzed intermolecular amination of C-H groups”Angew. Chem. Int. Ed.2007,46, 5184.