发表文章(#:共同第一;*:共同通讯)
1) Huang H*#,Zhu W#, Fu Z#, Huang B#, Xiong Y#, Cao D, Ye Y, Chang Q, Li W, Li L, Zhou H, Niu X, Zhang W.Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O,Structure, 2024, in press
2) Huang B#, Cao D#, Yuan X, Xiong Y, Chen B, Wang Y, Niu X, Tian R,Huang H*. USP7 Deubiquitinates KRAS and Promotes Non-Small Cell Lung Cancer,Cell Rep, 2024, 43(11):114917.
3) Liu M#, Li J#, Liu W#, Yang Y#, Zhang M, Ye Y, Zhu W, Zhou C, Zhai H, Xu Z*, Zhang G*,Huang H*. The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors,Angew Chem Int Ed, 2023, 9;62(41):e202309657
4) Cao D#, Duan L#, Huang B#, Xiong Y, Zhang G*,Huang H*, The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING,Sci. Signal., 2023,16(783):eadd0082.
5) Xiong Y#, Huang B#, Yang Y, Fu X, Fu Z, Xu H, Liu M, Cao D, Zhang M, Yang H, Niu X, Yu C,Huang H, Papain-like proteases from seven human-infecting coronaviruses differ in substrate selectivity and innate immune suppression,Sci. Signal., 2023,16(783):eade1985.
6) Fu Z#, Huang B#, Tang J#, Liu S#, Liu M, Ye Y, Liu Z, Xiong Y, Zhu W, Cao D, Li J, Niu X, Zhou H, Zhao YJ, Zhang G*,Huang H*,The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery,Nat. Commun.2021;12(1):488.
7) Ye Y#, Xiong Y#,Huang H., Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8,Commun Biol.2020;3(1):752.
8) Daou S#, Talukdar M#, Tang J#, Dong B, Banerjee S, Li Y, Duffy NM, Ogunjimi AA, Gaughan C, Jha BK, Gish G, Tavernier N, Mao D, Weiss SR,Huang H*, Silverman RH*, Sicheri F*, A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency,Proc Natl Acad Sci U S A. 2020;117(40):24802-24812.
9) Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F, Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon induced antiviral activity. Mol. Cell.2014; 53, 221-34
10) Huang H*, Ceccarelli DF*, Orlicky S*, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F, E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.Nat. Chem. Biol.2014 10, 156-63